Environmental Exposure Chamber (EEC)
for alergen provocation



Environmental exposure chambers (EECs) aim to achieve a stable and reproducible allergen exposure under the highly-standardized environmental conditions. Pollen counts are subject to strong local, seasonal and diurnal variations and are affected by confounding environmental conditions such as rain, temperature, humidity, and wind. The same is true for house dust mite allergens, where allergen concentration may differ in different housings. The use of environmental exposure chambers (EECs) provides standardized and validated well-defined, stable and reproducible allergen exposure under highly-standardized environmental conditions. This method is especially suitable for clinical trial both of pharmacological and immunotherapy products, where a bias by rescue medication is avoided but at the same time controlled symptom scoring after allergen exposure can be obtained.

The EEC at the "ALL-MED" Medical Research Institute has been standardized for stable environmental conditions (temperature, humidity, CO2) allergen particle content per m3 and clinically validated for mixed grass pollen allergens as well as house dust mite mite allergen Dermatophagoides pteronyssinus. Currenttly clinical studies and routine diagnostic tests involving patients sensitized to either grass pollen or house dust mite are performed.